11^th Asia Pacific Congress on Dental and Oral Health July 25-27, 2016 Bangkok, Thailand

The cutaneous sinus tract is an uncommon disease. Occasionally dental problem cause the pathologic breaking out from intrabony lesion of maxilla or mandible directly to skin drainage, swelling, or abscess. It is difficult to diagnose exactly of odontogenic cutaneous sinus tract for dentists or dermatologists except experienced clinicians or previously known clinicians. It is often misdiagnosed as warts, acne, dermatitis, or even malignant. Once patients were misdiagnosed, many patients may be treated with repeated surgical excisions, biopsies, and antibiotic medications, but most of them could be frustrated with the recurrence of disease. There are several methods for differential diagnosis of odontogenic cutaneous sinus tract - such as GP cone tracing, conventional computed tomography(CT), periapical x-ray imaging, and cone beam computed tomography(CBCT). If proper dental diagnosis and treatment is provided, cutaneous sinus tract can be healed without complications and recurrences. This case report describes the diagnosis and treatment of odontogenic cutaneous sinus tract that referred from medical doctors.

Dr. Berkay Tolga Suer has completed his graduate degree at the age of 22 years from Aegean University and pHD degree from Gulhane Military Medical Academy (GATA) at Ankara. He is a clinical associate professor of the oral and maxillofacial surgery department at GATA Haydarpasa Teaching Hospital in Istanbul. He has published more than 30 papers in reputed journals.

The term of odontogenic keratocyst was first coined by Philipsen in 1956. Lately World Health Organisation (WHO) is designated this lesion as a keratocystic odontogenic tumour (KOT) due to its aggressive and infiltrative behavior. Historically, this lesion is treated by the way of enucleation, marsupialization, peripheral ostectomy, resection or combination of these modalities. Because of its high recurrence rate, clinitians has been tried different modalities alternative to aggressive resection. Technique. 31-year-old otherwise healthy male patient was referred to our department from the department of corrections with incidental findinds of a big radiolusent lesion on his mandible after a altercations between inmates. Patient’s medical history revealed that the patient was treated for KOT in the same location 4 years ago in our facility. Patient file showed that the intial treatment modality for KOT was marsupialization only and it took about 12 months and resulted with full resolution of the lesion. Afterwards, the patient haven’t showed up any follow-up examination due to his incarceration. The radiographic examination showed a big radiolusent lesion on the patients left mandibular angulus and corpus region. The patient was admitted to our clinic. due to recurrence of the first KOT, treatment modality for this lesion was changed. Enucleation, aggressive curettage and Carnoy solution application was adopted as the treatment modality. This case once proven that the utilization of the marsupialization for KOT treatment is the least acceptable definitive treatment due to high recurrence rate of this lesion.

Kee-Yeon Kum is the Director of Clinical Services, Professor at Seoul National University Dental Hospital/School of Dentistry· Conservative Dentistry/Endodontics.

Objective: Calcium silicate (Ca3SiO5) has increasingly attracted attention as a canal obturation material due to superior seal and enhanced biocompatibility. This study evaluated the hydration behavior and radiopacity of a novel zirconium-added calcium silicate with a commercial OrthoMTA (BioMTA) cement. Material and Methods: Zirconium (Zr)-added calcium silicate cements was synthesized by solid state reaction using CaO and SiO2 as starting materials and zirconium propoxide (ZrO2) as Zr precursor. CaO and SiO2 was mixed thoroughly in anhydrous ethanol with various amount of Zr precursor (0.001~0.2 mol%). After drying, as-prepared powder was annealed at 1400°C for 3h in air. Hydration behavior (distilled water/power ratio=0.3) of Zr-added Ca3SiO5 and OrthoMTA was compared according to ISO 6876 standard and the hydration character was observed by SEM, XRD, STEM, and EDS. Five block specimens (2mm thickness, 5mm in diameter) of each cement group were compared using step wedge radiography. Results: Zr-added Ca3SiO5 had comparable radiopacity to OrthoMTA. The second phase CaZrO3 was increased by Zr in a dose-dependent manner, and stacked on the facet of Ca3SiO5. Setting time of Zr-added Ca3SiO5 was within 2 hr, whereas OrthoMTA was 5 hr. Conclusion: Zr-added calcium silicate ceramic showed comparable radiopacity and shorter curing time than OrthoMTA. Keywords: calcium silicate, hydration behavior, radiopacity, zirconium-added calcium silicate ceramic

Mohammad Reza Hajiani-Asl is a Clinical Laboratory Technologist (Medical Laboratory Sciences) and currently Student of Bs.c in Accounting and Finance. He has 4 years working experience in the cutting-edge laboratories such as; The Persian Gulf Marine Biotechnology Research Center and Animal Lab at Bushehr University of Medical Sciences, Bushehr, Iran. He has more than 10 published conference and journal articles. Currently he cooperates in the publication of Genetics of Dentistry book. His major interest in Research is the Stem Cells Technology Specially Dental Stem Cell Application and its Bio banking.

Dental Stem cells like all other types of stem cells are Undifferentiated cells which means, they have no any tissue-specific construction. Dental Stem cells are kind of Multipotent cells which means this type of unique cells can differentiation into the different types cell from all organs; and they have the Self-renewal potential which means they can produce the exact same cells to conserve the interminable of the resource. Dental Stem cells are easily accessible and lower tendency to malignancy than other types of stem cells. There are two types of stem cells; Embryonic Stem Cells and Adult Stem Cells. Dental Stem Cells are one of the significant type of Adult Stem cells and originated and isolated from different oral and maxillofacia area. These stem cells characterized according their source; the most important categories are Dental pulp stem cells (DPSCs) which originate from tooth pulp and can producing ectopic dentin in the immunocompromized mice, Stem cells from exfoliated deciduous teeth (SHED) which isolated from deciduous teeth, Periodontal ligament stem cells (PDLSCs) which originate from periodontal ligament, Stem cells from apical papilla (SCAP) which originate from apical papilla and capable to form odontoblast like cells and Dental follicle progenitor cells (DFPCs) which originate from dental follicle. The advantages of various types of Dental Stem Cells are; high plasticity, Perfect for stem cell banking (cryopreserved for long time), acceptable interaction with growth factors and etc. these cells can be used for bone repair, salivary glands repair, teeth regeneration and etc.

Dr Meghdad Khanian Mehmandoost Sofla Oromaxillofacial Surgeon (OMFS), was born on 1981 in Tehran, Iran. He is Assistant Professor at Oro Maxillofacial Department, Faculty of Dentistry, Bushehr University of Medical Sciences, Bushehr, Iran. He completed his DDS at Babol University of Medical Sciences in 2006; and completed his residency in Oromaxillofacial Surgery at Ahvaz Jundishapur University of Medical Sciences in 2013. He has 7 accepted and published papers in peer reviewed journals.

Stem cells are kind of cells with unique characteristics. This highlighted traits that make Stem cells persuasive and attracting in research and to design novel therapeutic approaches are Undifferentiated nature which means, they have no any tissue-specific construction; Pluripotency which means this type of magic cells can differentiation into the different types cell from all organs; and Self-renewal which means they can produce the exact same cells to conserve the everlasting of the resource. They can be derived from various tissues and classified according its origin. Stem cells which originated from embryo called Embryonic stem cell (ESC). Those derived from adults called Adult stem cell (ASC), such as Hematopoietic stem cell (HSC), Mesenchymal stem cell (MSC) and Induced pluripotent stem cell (iPS). The type which used in current practice is ASC and the best resources to derive ASC are; Bone marrow, Adipose tissue, oral & maxillofacial region and Dental pulps. Dental stem cells can be differentiated to the other tissues and also can being used for maxillofacial Injuries. This type of stem cells is very useful and applicable because of its proliferative and differentiative abilities and accessibility. Dental Stem cells predominantly contain MSC. Clinical applications of this kind of stem cells are Regeneration of dentin/pulp; because Dental pulp tissue has the potential to regenerate dentin in response to injuries. the periodontal structures regenerate, like periodontal ligament; Regeneration of craniofacial defects and tooth regeneration and etc.

Kyungsun Kim has completed her Master Degree at the age of 27 years from Yonsei University, Korea. She is now in a doctoral course at Seoul National University, Korea. She has majored in microbiology and now in oral microbiology at Department of Oral Microbiology and Immunology. She has published more than 4 papers in reputed journals and attended many conferences at home and abroad.

To analyze adhesion of periodontopathogens to self-ligating brackets (Clarity-SL [CSL], Clippy-C [CC] and Damon Q [DQ]) and identify the relationships between bacterial adhesion and oral hygiene indices. Central incisor brackets from the maxilla and mandible were collected from 60 patients at debonding after plaque and gingival indices were measured. Adhesions of Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), Prevotella intermedia (Pi), Fusobacterium nucleatum (Fn), and Tannerella forsythia (Tf) were quantitatively determined using real-time polymerase chain reactions. Factorial analysis of variance was used to analyze bacterial adhesion in relation to bracket type and jaw position. Correlation coefficients were calculated to determine the relationships between bacterial adhesion and oral hygiene indices. Total bacteria showed greater adhesion to CSL than to DQ, while Aa, Pg and Pi adhered more to DQ than to CSL. CC showed an intermediate adhesion pattern between CSL and DQ, but it did not differ significantly from either bracket type. Adhesion of Fn and Tf did not differ significantly among the three brackets. Most bacteria were detected in greater quantities in the mandibular than in the maxillary brackets. Plaque and gingival indices were not strongly correlated with bacterial adhesion to brackets. Considering that Aa, Pg, and Pi adhered more to DQ in the mandibular area, orthodontic patients with periodontal problems should be carefully monitored in the mandibular incisors where the distance between the brackets and gingiva is small, especially when DQ is used.

Myo Min Thane was graduated Bachelor of Dental Surgery from University of Dental Medicine, Yangon, Myanmar. Then, he worked as a Research Officer at Asean Costs In Oncology Study (ACTION Study-Myanmar), Department of Medical Research in Yangon for three years. He is a member of Myanmar Dental Association and volunteer dental surgeon in the Oral Cancer Screening Program organized by Myanmar Society of Oral Medicine and Pathology.

Dental professional has a key role in the prevention of oral cancer by early detection of any suspicious oral lesions. The purpose of the study is to evaluate the various forms of tobacco usage and the occurence of oral lesions among the people living in Hpa An, Kayin State. In this study, 337 participants were underwent for oral screening and 73 participants had various type oral habits. Male:female ratio was 1:1.5. Commonest oral habits were chewing betel quid alone (69.8%) followed by chewing & smoking(12.32%), chewing, smoking and drinking(9.5%), smoking alone(4.1%), smoking&drinking(2.7%) and chewing&drinking(1.3%) respectively. On examination, 19 out of 73 had chewer mucosa (26.02%) and 12 out of 73 had suspicious oral lesions(16.44%). After conducting toluidine blue staining, 7 out of 12 suspicious cases were toluidine blue stain positive. 6 cases were underwent for oral brush biopsy and excisional biopsy was done in one case. One case did excisional biospy along with oral brush biopsy. Epithelial dysplasia were found in 6 cases and histological examination of excisional biopsy was compatible with oral squamous cell carcinoma (well differentiated). Collectively, among the tobacco users(n=73), 6 cases of oral potentially malignant disorders and one oral squamous cell carcinoma were detected (~10.1%). Oral cancer screening at Kayin State Hospital showed effectiveness of oral screening among high risk group for detection of suspicious oral lesions. Therefore, detrimental effect of smokeless and smoking tobacco was significantly involved in the causative factors of OPMDs and oral cancer.

Pritha Pal has completed her M.Sc. in Biotechnology at the age of 22 years from Presidency College affiliated under the University of Calcutta, having ranked 1st Class 1st. She is undergoing her PhD in the Department of Genetics, Vivekananda Institute of Medical Sciences, Ramakrishna Mission Seva Pratishthan, Kolkata; registered under Calcutta University. She has published 2 papers in reputed journals in the field of cancer genetics and environmental studies.

Human Papilloma Virus (HPV) infection has been associated with the development of oral carcinoma. Since West Bengal is an arsenic prone area and arsenic toxicity leads to cancer, this metal toxicity is studied as a co-factor in the development of this disease. We have aimed to find out any possible correlation between HPV infection and oral carcinoma along with this metal toxicity. Ethical clearance for this study was obtained from the Ethics Committee of Vivekananda Institute of Medical Sciences, Ramakrishna Mission Seva Pratishthan. Patients attending our hospital were screened for the presence of oral premalignant and malignant lesions. The subjects were administered a standard questionnaire. The buccal swab and hair samples (107 cases and 50 controls) were collectedafter obtaining informed consent from all the corresponding subjects, and were analysed for detection of HPV 16 DNA and arsenic level analysis respectively. 22.5% of malignant samples showed the presence of HPV 16 DNA. 80% of cases showed their arsenic count above the safe limit (0.8µg/g). A considerable percentage of malignant samples showed the presence of HPV16 DNA, indicating that there may be a correlation between HPV infection and oral malignancy in this population. A higher percentage of cases showing an elevated arsenic count states a possible link between arsenic toxicity and the development of this disease. However, a higher population size and statistical analysis are required for a proper conclusion.